| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Polymorphism of human haptoglobin and its clinical importance
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| Autores: |
Wobeto,Vânia Peretti de Albuquerque
Zaccariotto,Tânia Regina
Sonati,Maria de Fátima
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| Data: |
2008-01-01
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| Ano: |
2008
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| Palavras-chave: |
Haptoglobin
Hemoglobin
Genetic polymorphisms
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| Resumo: |
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400002
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572008000400002
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.31 n.3 2008
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| Direitos: |
info:eu-repo/semantics/openAccess
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